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Adipose-Derived Stem Cell-Based Therapy Shows Promise in Knee Osteoarthritis

June 27, 2016

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Single intra-articular injection of autologous adipose-derived stem cells may improve pain and mobility

For patients with knee osteoarthritis, a single intra-articular injection of autologous adipose-derived stromal cells (ASCs) may reduce pain and inflammation, according to research published in Stem Cells Translational Medicine.

Lapeyronie University Hospital in Montpellier, France, and colleagues focused on 18 French and German men and women, aged 50 to 75, with severe knee osteoarthritis for at least a year before joining the study on stem cell therapy for knees. Between April 2012 and December 2013, all of the patients first underwent liposuction to extract fat-derived samples of specific stem cells. One-third of the patients received a single, low-dose injection of autologous adipose-derived stem cells directly into their knee. Another third received a medium-dose injection, and the remaining group received a high-dose injection.

After six months, the study team found that all three groups showed improvements in terms of pain, function, and mobility. However, only those in the low-dose group were determined to have statistically significant improvements in terms of both knee pain and function recovery. Apart from one case of chest pain (about three months after the injection), only a few patients experienced mild side effects.

“Our data suggest that the intra-articular injection of ASCs is a safe therapeutic alternative to treat severe knee osteoarthritis patients,” the authors write. “A placebo-controlled double-blind phase IIb study is being initiated to assess clinical and structural efficacy.”

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StemGenex Medical Group is referring to this article merely to share important information relating to stem cell therapies. The information is not endorsed by StemGenex Medical Group and should not be construed as statements made by it.  Original article published on 6/27/2016 can be read here

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